Google Releases AlphaGenome Atlas, a Full Map of Human Gene Variations

Google has launched AlphaGenome Atlas, a platform that covers functional predictions for 9 billion single-nucleotide variants in the human genome, making it the most complete catalog of how gene mutations affect molecules. It's free for academic use. The platform is based on DeepMind's AI model AlphaGenome, and uses large-scale precomputation to build a full map of genome-wide DNA variants. It also introduces the AVI score, which combines the strengths of AlphaGenome and AlphaMissense to help researchers quickly rank variants. The dataset is huge, over 1 petabyte, and includes molecular effect predictions, AVI scores, and feature attributions. Outside research teams have already used it to find a DNM1 gene variant linked to epileptic encephalopathy, and in a UK Biobank study, they found 22% more non-coding gene associations. The platform is now open to academic researchers, and free for non-commercial use.